Category: via Facebook

Here, we report that several months after the second vaccination, SARS-CoV-2-specific antibodies were increasingly composed of non-inflammatory IgG4, which were further boosted by a third mRNA vaccination and/or SARS-CoV-2 variant breakthrough infections.

IgG4 antibodies among all spike-specific IgG antibodies rose on average from 0.04% shortly after the second vaccination to 19.27% late after the third vaccination.

This induction of IgG4 antibodies was not observed after homologous or heterologous SARS-CoV-2 vaccination with adenoviral vectors.

Importantly, this class switch was associated with a reduced capacity of the spike-specific antibodies to mediate antibody-dependent cellular phagocytosis and complement deposition.

Since Fc-mediated effector functions are critical for antiviral immunity, these findings may have consequences for the choice and timing of vaccination regimens using mRNA vaccines, including future booster immunizations against SARS-CoV-2.

Class switch towards non-inflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination.

https://www.science.org/doi/10.1126/sciimmunol.ade2798

AstraZeneca AZD1222 is worse than Pfizer BNT162b2 and Moderna mRNA-1273 (they’re all garbage, really), but since mRNA Pfizer and Moderna at least attempt (but fail) to immobilize the toxic spike proteins in place, whereas AstraZeneca’s are floating around freely attached to an adenovirus, with regards to long-term immune system impairment, I guess AstraZeneca wins this round.

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We show that the initially high mRNA vaccine-induced blood and salivary anti-S IgG levels, particularly IgG1, markedly decrease over time and approach the lower levels induced with the adenovirus-based vaccine.

All three vaccines induced, contrary to the short-term anti-S IgG1 response with high sialylation and galactosylation levels, a long-term anti-S IgG1 response that was characterized by low sialylation and galactosylation with the latter being even below the corresponding total IgG1 galactosylation level.

Instead, the mRNA, but not the adenovirus-based vaccines induced long-term IgG4 responses – the IgG subclass with inhibitory effector functions.

Furthermore, salivary anti-S IgA levels were lower and decreased faster in naïve as compared to pre-infected vaccinees.

Repeated immunization of naïve individuals with the mRNA vaccines increased the proportion of the IgG4 subclass over time which might influence the long-term Ab effector functions.

These data shed light on these novel vaccine formats and might have potential implications for their long-term efficacy.

mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses compared to an adenovirus-based vaccine.

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1020844/full?s=09#B75

IgG4 antibodies are non-neutralizing antibodies, akin to antibodies produced in response to allergies. Repeated immunization with mRNA vaccines sensitizes a long-term allergic response to COVID, leaving you more susceptible than you would otherwise have been.

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Excess non-COVID deaths by age, sex, and date, Office for Health Improvement and Disparities (OHID), formerly Public Health England.

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Get your Omicron bivalent booster shots, vaccinate your 6 month old too while you’re at it, do it for Joe Biden.

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I know what I’m doing, mind your own business.

Imagine believing there exist more diversified tax-efficient stocks than Berkshire Hathaway, Warren Buffet literally invented not paying taxes.

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I’ve also been buying 3x leveraged Nasdaq ETF TQQQ through a 75% decline, also now up +11.17% in 5 days. Let’s see what it can do.

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